A fluorescent STING ligand sensor for identifying honokiol as a STING agonist with antitumor activity
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Excel datasheets for graphs and Uncropped immunoblotting
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2025-06-09
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Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine–Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING)
We describe novel STING-activating cyclic dinucleotides whose constituent nucleosides are adenosine and inosine and that vary by ribose substitution, internucleotide linkage position, and phosphate mo
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Structure–Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists
Activation of the stimulator of interferon gene (STING) has emerged as an exciting immuno-oncology therapeutic strategy; however, the first-generation STING agonists, cyclic dinucleotide (CDN) analogu
Figshare2021-01-20 更新30
Characterization of a Novel Compound that Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner
A small molecule termed M04 behaves as a novel agonist of human STING. Importantly, we find that the molecule exhibits a differential ability to activate STING based on the allelic variant examined. F
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STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 12
STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 12 Descriptor: 4-(6-{3-[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-4-yl]propyl}-5-methoxy-1-benzothiophen-2-yl)-4-oxobutan
Protein Data Bank Japan2023-10-11 更新40
Structure of human STING in complex with MK-1454
Structure of human STING in complex with MK-1454 Descriptor: (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulf
Protein Data Bank Japan2023-10-18 更新30
