Inhibition of human CYP11B1 and CYP11B2 by references I–III and compounds 1–21.
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[a]Hamster fibroblasts expressing human CYP11B1 or CYP11B2, respectively; substrate: deoxycorticosterone, 100 nM.[b]SF: selectivity factor = IC50 CYP11B1/IC50 CYP11B2.[c]Fad: fadrozole; nd: not determined.
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2015-12-02
