What are the factors that contribute to aggression in patients with co-occurring antisocial personality disorder and substance abuse?

Abstract Background A significant number of individuals with high levels of aggression have substance use disorder problems. Objective This study aimed to evaluate the effect of substance use disorder on aggression in young men with Antisocial personality disorder (ASPD). Methods This cross-sectional study included 328 patients and were diagnosed with ASPD with a comorbidity of substance use disorder, along with 111 healthy young male subjects. Results The total aggression scores of the patients with a diagnosis of ASPD were significantly higher than those of the healthy group (p