Leonurine–dilated cardiomyopathy: code and source data

Code and source data for "Leonurine engages ABCG2 in cardiomyocytes and HTR4 in fibroblasts: a target-to-structure analysis anchored in human dilated cardiomyopathy transcriptomes". Every figure in the paper is produced by script from the tables in this archive. The archive contains the analysis and figure pipeline (R and Python), the source tables the figure scripts read, the statistical outputs reported in the text and supplementary tables, and the docked complexes with their search-box definitions and per-run results. The pipeline re-checks 178 numerical assertions against the source tables as it runs. Transcriptomes are from the Gene Expression Omnibus (GSE57338, GSE21610, GSE17800, GSE116250). Single-nucleus data are from Reichart et al. (Science 2022) and Koenig et al. (Nat Cardiovasc Res 2022). Protein structures are PDB 8PY4 (ABCG2) and 7XT8 (5-HT4 receptor). Leonurine targets were queried from SwissTargetPrediction, the Similarity Ensemble Approach and the Comparative Toxicogenomics Database in October 2026. This archive redistributes derived tables only. The three large expression matrices are not included; source_data/README_expression_matrices.txt gives the recipe that regenerates them from the GEO series. The primary datasets remain with their original repositories under their own terms. Code is released under the MIT licence; derived data tables under CC BY 4.0.