Data for SPINDLE2

Data produced during research project "NEURONAL REPROGRAMMING IN SCHIZOPHRENIA: A TRANSLATIONAL APPROACH TO UNRAVEL SLEEP ENDOPHENOTYPES", promoted by prof. Armando D'Agostino RESEARCH OBJECTIVES: 1- precise characterization of sleep endophenotype and genomic profile in a group of patients with Schizophrenia, recorded during the first episode of psychosis (FEP) and in matched control samples. Research steps: 1.1 - Detailed characterization of sleep endophenotype and genomic profile in a group of patients with Schizophrenia, recorded during the first episode of psychosis (First Episode Psychosis, FEP) and in matched control samples. 1.2 - Follow-up psychodiagnostic assessments to obtain more information on the correlation between thalamo-cortical dysfunction (altered spindle activity) and longitudinal clinical phenotype in all FEP subjects with a confirmed diagnosis of Schizophrenia (SCZ). 1.3 - Blood sampling of subjects with a confirmed diagnosis of SCZ for a genetic characterization aimed at estimating the load of common variants at individual level, stratifying them according to risk. Selection on the basis of particular allelic variants and/or significant impairment of the Thalamic Reticular Nucleus (TRN), suggested by higher sleep spindle deficits, of patients with SCZ for cellular reprogramming. 2 - in follow-up sample, identification of neural correlates, focusing on structural and functional brain connectivity related to gamma-band oscillations, using functional magnetic resonance imaging (fMRI), structural magnetic resonance imaging (sMRI), and electrophysiology (in particular simultaneous electroencephalography with fMRI (EEG - fMRI), at rest and during a task). 3 - generation of GABAergic interneurons from patient-specific induced pluripotent stem cells (human iPSCs, hiPSCs) to identify specific molecular and functional alterations that reflect GABAergic dysfunctions at the cellular level.