Fibroblast-derived exosomal microRNA regulates NKX3-1 expression in androgen-sensitive, androgen receptor-dependent prostate cancer cells

The expression profiling of exosomal miRNAs produced by fibroblasts (human prostate stromal and three types of primary cultured prostate fibroblasts) revealed that certain fibroblast-produced exosomes may be involved in the suppression of oncogenic dedifferentiation in prostate cancer cells. In this study, miRNA expression profiling was obtained for exosomal miRNAs produced by fibroblasts (human prostate stroma and three types of primary cultured prostate fibroblasts).