Correlation between CDK1 activating machinery components and chemotherapeutic agents in NCI60 cell line panel.

A COMPARE analysis was performed by correlating protein levels of CDK1 activating machinery components with GI50 (concentration producing 50% growth inhibition) values of chemotherapeutic agents in NCI60 human cancer cell lines. A positive Pearson Correlation Coefficient (PCC) indicates that the greater abundance of the target may associate with sensitivity to the drug, whereas a negative correlation is indicative of more target conferring cellular resistance to the given drug.