Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under low-salt conditions

Complex structure of human protein kinase CK2 catalytic subunit with a thieno[2,3-d]pyrimidin inhibitor crystallized under low-salt conditions Descriptor: 3-[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanylpropanoic acid, CHLORIDE ION, Casein kinase II subunit alpha, ... Authors: Niefind, K, Bischoff, N, Yarmoluk, S.M, Bdzhola, V.G, Golub, A.G, Balanda, A.O, Prykhod'ko, A.O. Deposit date: 2016-10-18 Release date: 2017-01-18 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.935 Å) Cite: Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Pharmaceuticals, 10, 2017

低盐条件下结晶得到的人类蛋白激酶CK2催化亚基与噻吩并[2,3-d]嘧啶（thieno[2,3-d]pyrimidin）类抑制剂的复合晶体结构
描述符：3-[5-(4-甲基苯基)噻吩并[2,3-d]嘧啶-4-基]硫基丙酸、氯离子、酪蛋白激酶II亚基α（Casein kinase II subunit alpha）等
作者：Niefind K、Bischoff N、Yarmoluk S.M、Bdzhola V.G、Golub A.G、Balanda A.O、Prykhod'ko A.O.
入库日期：2016-10-18
发布日期：2017-01-18
最后修改日期：2024-01-17
研究方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.935埃
引用文献：《通过与黄酮醇类及噻吩并[2,3-d]嘧啶类抑制剂的复合晶体结构揭示两种人类蛋白激酶CK2催化亚基旁系同源物的结构高变异性》，《Pharmaceuticals》，2017年，第10卷