USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES.

USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES. Descriptor: N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide, PAPAIN Authors: Lalonde, J.M, Zhao, B, Smith, W.W, Janson, C.A, Desjarlais, R.L, Tomaszek, T.A, Carr, T.J, Thompson, S.K, Yamashita, D.S, Veber, D.F, Abdel-Mequid, S.S. Deposit date: 1998-08-12 Release date: 1999-08-12 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites. J.Med.Chem., 41, 1998

以木瓜蛋白酶（papain）为模型开展组织蛋白酶K（cathepsin K）抑制剂的基于结构设计：两类木瓜蛋白酶-抑制剂复合物的晶体结构证实其可结合S'亚位点。描述符：N-[(苄氧基)羰基]-L-亮氨酰基-N-[(2S)-1-羟基-4-甲基戊烷-2-基]-L-亮氨酰胺，木瓜蛋白酶（papain）。作者：Lalonde, J.M.、Zhao, B.、Smith, W.W.、Janson, C.A.、Desjarlais, R.L.、Tomaszek, T.A.、Carr, T.J.、Thompson, S.K.、Yamashita, D.S.、Veber, D.F.、Abdel-Mequid, S.S.。提交日期：1998-08-12。发布日期：1999-08-12。最后修改时间：2024-10-23。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.2埃（Å）。引用文献：以木瓜蛋白酶为模型开展组织蛋白酶K抑制剂的基于结构设计：两类木瓜蛋白酶-抑制剂复合物证实其结合S'亚位点。《药物化学杂志》（J.Med.Chem.），第41卷，1998年。