Design and Evaluation of Salts between N‑Trityl Amino Acid and tert-Butylamine as Inclusion Crystals of Alcohols

Salts between N-trityl amino acids (Ala, Val, Leu, Ile, Phe, and phenylglycine) and tert-butylamine are examined in terms of inclusion ability for alcohols. An X-ray crystallographic study elucidated the column structures, hydrogen-bond network, and phenyl–phenyl interactions. It also found that tert-butylammonium N-trityl phenylalanate was superior to other salts of amino acids at including several alkyl alcohols. When the salt included 1-chloro-2-propanol as a guest alcohol, the enatioselectivity of inclusion reached up to 69% ee (S-form).