Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders

Neurodegenerative diseases represent
a challenge for biomedical
research due to their high prevalence and lack of mechanism-based
treatments. Because of the complex pathology of neurodegenerative
disorders, multifunctional drugs have been increasingly recognized
as potential treatments. We identified homobivalent γ-carbolinium
salts as potent inihitors of both cholinesterases, N-methyl-d-aspartate receptors, and monoamine oxidases. Homobivalent
γ-carbolines displayed similar structure–activity relationships
on all tested targets and may present promising designed multiple
ligands for the treatment of neurodegenerative disorders.