Identification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia

Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective targeted therapeutics. In order to find the genes regulated by miR455 in HTLV-1 positive cells, we sought the target genes of miR455 by overexpressing miR455 in HTLV-1 positive cells.