Analysis of regulatory landscape of chromatin in cortical PV-cells during brain development in wild-type and Nipbl mutant mice. Mus musculus

During the development of mammalian brain, maturation of parvalbumin-positive interneurons (PV-cells) is essential for proper rewiring of neuronal circuit by experience. This project aims to clarify changes in the regulatory landscape of chromatin of PV-cells during postnatal development in mouse cerebral cortex. In addition, the role of Nipbl, which is mutated in Cornelia de Lange syndrome including mental retardation, in the regulation of chromatin and gene expression in PV-cells is examined.