Genomics of Prostate Cancer

Cohort 1: Active surveillance for newly-diagnosed prostate cancer
Inclusion criteria:

Initially diagnosed with low or favorable intermediate-risk prostate cancer and considered suitable for Active Surveillance
Underwent at least one follow-up biopsyRemained on active surveillance following at least one follow-up biopsy or progressed and underwent primary therapy

Cohort 2: Immunogenic prostate cancer
Inclusion criteria:

Underwent radical prostatectomy for NCCN high-risk prostate cancer
Prostate specimen harbored area of PD-L1 tumor expression >5% and/or dense CD3 infiltrate

Cohort 3: Lethal prostate cancer
Inclusion criteria:

Consented to rapid autopsy following death attributed to progression of metastatic genitourinary cancers
Biospecimens available from matched primary and metastatic disease
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