Genomics of Prostate Cancer

Cohort 1: Active surveillance for newly-diagnosed prostate cancer Inclusion criteria: Initially diagnosed with low or favorable intermediate-risk prostate cancer and considered suitable for Active Surveillance Underwent at least one follow-up biopsyRemained on active surveillance following at least one follow-up biopsy or progressed and underwent primary therapy Cohort 2: Immunogenic prostate cancer Inclusion criteria: Underwent radical prostatectomy for NCCN high-risk prostate cancer Prostate specimen harbored area of PD-L1 tumor expression >5% and/or dense CD3 infiltrate Cohort 3: Lethal prostate cancer Inclusion criteria: Consented to rapid autopsy following death attributed to progression of metastatic genitourinary cancers Biospecimens available from matched primary and metastatic disease ]]> N/A]]>