The Influence of Perilipin 5 Deficiency on Gut Microbiome Profiles in Murine Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) and MAFLD-Hepatocellular Carcinoma

We conducted a study to investigate the alterations in fecal microbiome composition in wild type (WT) and Plin5-deficient (Plin5-/-) mice models of MAFLD and MAFLD-induced HCC (MAFLD-HCC). We utilized 16S rRNA gene sequencing analysis to profile the composition of gut bacteria in fecal samples.