Conservation of chromatin loops between mouse and human beta cells

Studying the conservation and differences of regulation between human and mouse helps understand gene regulation on mouse models. Chromatin loop is an important gene regulatory mechanism to drive the 3D regulation between genes and their regulatory elements. Here, we performed eHi-C to profile genome wide contacts in mouse strains B6 and CAST islet beta cells, together with the loops identified in human islet alpha and beta cells from previous studies (GSE195523). The results show that the conserved chromation loop and open chromatin regions highlight the function of T2D risk loci and improve our understanding in islet biology. 3D genome structure mapping in beta cells from mouse starin B6 and CAST using easy Hi-C method