CancerHERVdb

In summary, the CancerHERVdb allows cross-study comparisons, encourages data exploration, and informs about potential off-target effects of HERV-targeting treatments. IMPORTANCE Human endogenous retroviruses (HERVs), which in the past have inserted themselves in various regions of the human genome, are to various degrees activated in virtually every cancer type. While a centralized naming system and resources summarizing HERV levels in cancers are lacking, the CancerHERVdb database provides a consolidated resource for cross-study comparisons, data exploration, and targeted searches of HERV activation. The user can access data extracted from hundreds of articles spanning 25 human cancer categories. Therefore, the CancerHERVdb database can aid in the identification of prognostic and risk markers, drivers of cancer, tumor-specific targets, multicancer spanning signals, and targets for immune therapies. Consequently, the CancerHERVdb database is of direct relevance for clinical as well as basic research.总而言之，CancerHERVdb支持跨研究比较，助力数据探索，并可提示靶向人类内源性逆转录病毒（Human endogenous retroviruses，HERV）疗法的潜在脱靶效应。 研究意义：人类内源性逆转录病毒（Human endogenous retroviruses，HERV）曾整合至人类基因组的多个区域，且在几乎所有癌症类型中均存在不同程度的激活现象。目前学界尚未建立统一的命名体系，也缺乏汇总癌症中HERV表达水平的相关资源，而CancerHERVdb数据库则提供了一项整合性资源，可用于跨研究比较、数据探索以及HERV激活状态的定向检索。用户可获取从数百篇涵盖25种人类癌症类别的文献中提取的数据。因此，CancerHERVdb数据库可辅助识别预后与风险标志物、癌症驱动因子、肿瘤特异性靶点、跨癌种信号以及免疫疗法靶点。综上，CancerHERVdb数据库对临床研究与基础研究均具有直接的参考价值。

搜集汇总

背景与挑战

背景概述

CancerHERVdb是一个整合的人类内源性逆转录病毒（HERV）在癌症中表达数据的数据库，支持跨研究比较和数据探索。它基于数百篇文献覆盖25种人类癌症类别，提供按癌症类型、HERV家族和基因的搜索功能，有助于识别预后标志物和免疫治疗靶点。