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Diastereoselective Synthesis of CF<sub>3</sub>‑Substituted, Epoxide-Fused Heterocycles with β‑(Trifluoromethyl)vinylsulfonium Salts

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NIAID Data Ecosystem2026-03-09 收录
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CF3-substituted vinyl diphenylsulfonium triflate is an effective annulation reagent for the formation of α-CF3 substituted, epoxide-fused heterocycles (pyrrolidines, piperidines, and tetrahydrofurans). This simple method affords a variety of valuable heterocyclic building blocks in a highly diastereoselective manner (dr >20:1).

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2016-02-20
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