HAEMATOLOGICAL EFFECT OF ANTHOCLESTA NOBILIS ON POTASSIUM BROMATE-INTOXICATED RATS

Potassium bromate used widely in foods has been associated with various complications and much
attention has been drawn to the toxic effect of bromate on the organs like liver, kidney etc. In this study,
the effect of the ethanol extract of Anthocleista nobilisleaves on kidney and liver damages induced by
exposure to an acute dose of potassium bromate was measured using appropriate biomarkers.
Anthocleista nobilis, known commonly as Okpokoro, is extensively used in traditional medicine to
treat many disorders. Potassium bromate was induced through oral administration followed by oral
administration of ethanol extract of Anthoclesta nobilis at doses 200mg/kg body weight, 400mg/kg
body weight for 4 weeks, while the control group received distilled water and the positive control
group received the ascorbic acid and distilled water. At the end of the experiment, the rats were
sacrificed, body weight, relative organ weight, the parameters of the lipid. Treatment with ethanol
extract of Anthoclesta nobilis at doses of 200mg/kg body weight, 400mg/kg body weight and
800mg/kg body weight showed significant increase of the body weight in treated groups. Result shows
a significant increase in RBC, PCV, Hb and a significant decrease in WBC and PLT. Result also showed
a significant decrease in urea uric acid, creatinine, sodium, potassium, chlorine and bicarbonate at
(p<0.05). This study revealed that Anthoclesta nobilis was efficient in reducing and management of
potassium bromated induced systemic toxicity and be a potential source of control for oxidative stress
caused some environmental oxidants.