Crystal structure of compound 4f bound to large ribosomal subunit (50S) from Deinococcus radiodurans

Crystal structure of compound 4f bound to large ribosomal subunit (50S) from Deinococcus radiodurans Descriptor: (3aS,4R,7R,8S,9S,10R,11R,13R,15S,15aR)-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-2,6,14-trioxo-10-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}tetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-8-yl (2R)-4,4-dimethyl-2-(pyridin-3-yl)pyrrolidine-1-carboxylate, 23S ribosomal RNA, 50S ribosomal protein L11, ... Authors: Han, S, Marr, E.S. Deposit date: 2013-01-07 Release date: 2013-03-06 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates. Bioorg.Med.Chem.Lett., 23, 2013

耐辐射奇球菌（Deinococcus radiodurans）50S大核糖体亚基与化合物4f结合的晶体结构 结构描述：(3aS,4R,7R,8S,9S,10R,11R,13R,15S,15aR)-4-乙基-11-甲氧基-3a,7,9,11,13,15-六甲基-2,6,14-三氧代-10-{[3,4,6-三脱氧-3-(二甲氨基)-β-D-木己吡喃糖基]氧基}十四氢-2H-氧杂环十四烷并[4,3-d][1,3]恶唑-8-基 (2R)-4,4-二甲基-2-(吡啶-3-基)吡咯烷-1-羧酸酯、23S核糖体RNA（23S ribosomal RNA）、50S核糖体蛋白L11（50S ribosomal protein L11）等。作者：Han, S、Marr, E.S.。沉积日期：2013-01-07。发布日期：2013-03-06。最后修改日期：2024-10-30。实验方法：X射线衍射（3.6 Å）。引用文献：《针对耐药葡萄球菌与链球菌分离株具有活性的新型3-O-氨基甲酰红霉素A衍生物（氨基甲酰内酯类）》，《Bioorg.Med.Chem.Lett.》，第23卷，2013年。