Design of an Inversion Center between Two Helical Segments

A new strategy is proposed to control the relative orientation of two folded helical oligomers in
such a way that they diverge from an aromatic linker and have opposite helical handedness. Mutual steric
exclusion between the two helices results from the fact that they cannot be at the same time folded and on
the same side of the linker. The concept is validated using the helical conformations of oligoamides of
8-amino-2-quinolinecarboxylic acid, but it should be applicable to many families of oligomers and leads to
the first designed meso-helices.