crystal structure of the receptor tyrosine kinase Human HER2 (ERBB2) YVMA mutant kinase domain in complex with inhibitor compound 27

crystal structure of the receptor tyrosine kinase Human HER2 (ERBB2) YVMA mutant kinase domain in complex with inhibitor compound 27 Descriptor: 1-{(1R,3r,5S)-3-[(3M)-4-methyl-3-{3-methyl-4-[(1-methyl-1H-benzimidazol-5-yl)oxy]phenyl}-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-8-azabicyclo[3.2.1]octan-8-yl}propan-1-one, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Wang, J, Mou, T.C. Deposit date: 2023-09-18 Release date: 2024-06-12 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Discovery of Potent and Selective Covalent Inhibitors of HER2 WT and HER2 YVMA . J.Med.Chem., 67, 2024受体酪氨酸激酶人源HER2（ERBB2）YVMA突变体激酶结构域与抑制剂化合物27的复合物晶体结构。配体描述：1-{(1R,3r,5S)-3-[(3M)-4-甲基-3-{3-甲基-4-[(1-甲基-1H-苯并咪唑-5-基)氧基]苯基}-1H-吡唑并[3,4-d]嘧啶-1-基]-8-氮杂双环[3.2.1]辛烷-8-基}丙-1-酮，体系含氯离子、二(羟乙基)醚…… 作者：Wang J、Mou T.C. 存入日期：2023-09-18 发布日期：2024-06-12 最后修改日期：2024-10-30 解析方法：X射线衍射（分辨率1.69 Å） 引用文献：《HER2野生型与HER2 YVMA突变体强效选择性共价抑制剂的发现》，《J. Med. Chem.》，2024年，第67卷