MWU test significant regions.

Target regions with most significant p-values for Mann-Whitney U test distinguishing the frequency spectra of weak-to-strong (W2S) from strong-to-weak (S2W) mutations. Starred regions are also significant in the MK test (Table 2). offset: the estimated offset of the two spectra, normalized to 22 chromosomal samples, with positive values indicating W2S mutations shifted to higher derived allele frequencies. compare: the number of regions in 13 ctlreg50-62 (ctl) or 62 Seattle SNPs (sea) genic regions with a more significant p-value and positive W2S offset. p-value with mask columns are the p-values derived by omitting all segregating sites at the indicated number of bases from the center of the target region. The 5kbHi column gives the highest (least significant) p-value obtained by omitting all segregating sites in a set of overlapping 5kb windows centered at each 2.5kb in the target region. recomb: sex-averaged and male recombination rates from deCODE 1Mb regions. telo: distance of the region from the closer telomere measured in number of karyotype bands, where 0 is the telomeric band.