Novel and validated loci based on genome-wide association with platelet count and mean platelet volume in COGENT (novel loci are in bold).

*SNPs in locus reaching GWAS significant threshold (5×10−8).MAF = minor allele frequency; Chr = chromosome; SE = standard error; effect size = age-sex adjusted change in platelet count (109 L) or MPV (fL) per copy of minor allele; Maj = major; Min = minor; Het-P = Cochrane Q p-value to assess heterogeneity.#excluding cohorts that were included in the previous study16 that reported this SNP, the p-value was 8.6×10−7.