Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056

Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-DIPHOSPHATE, N-{[(3s,5s,7s)-adamantan-1-yl]methyl}-2-chloro-5-{3-[(3-hydroxypropyl)amino]propyl}benzamide, ... Authors: Oken, A.C, Ditter, I.A, Lisi, N.E, Krishnamurthy, I, McCarthy, A.E, Godsey, M.H, Mansoor, S.E. Deposit date: 2023-08-09 Release date: 2024-10-16 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (2.21 Å) Cite: P2X 7 receptors exhibit at least three modes of allosteric antagonism. Sci Adv, 10, 2024结合变构拮抗剂AZD9056的大鼠P2X7受体冷冻电镜（Cryo-EM）结构 配体描述：2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖、鸟苷-5'-二磷酸、N-[(3s,5s,7s)-金刚烷-1-基]甲基-2-氯-5-[3-(3-羟基丙基氨基)丙基]苯甲酰胺…… 作者：Oken A.C.、Ditter I.A.、Lisi N.E.、Krishnamurthy I.、McCarthy A.E.、Godsey M.H.、Mansoor S.E. 存档日期：2023-08-09 发布日期：2024-10-16 最后更新日期：2025-05-28 实验方法：电子显微镜（分辨率2.21埃） 引用文献：P2X7受体至少存在三种变构拮抗模式。《科学进展》（Science Advances），第10卷，2024年