VYD2311 (Pemivibart) Escape Co-occurrence Mutations in 42,835 SARS-CoV-2 Genomes from 2025

This dataset contains amino acid mutations co-occurring with VYD2311 (Pemivibart) escape constellations (R346T, S371F, K444T, N460K, F486P) across 10 canonical SARS-CoV-2 proteins in 42,835 genomes from 2025. Includes per-genome mutation profiles, VYD2311 constellation assignments, and corrected genome counts. CORRECTED GLOBAL SUMMARY: VYD2311 Co-occurrence Analysis (2025)================================================================Total VYD2311+ genomes: 42,835Total co-occurring mutations: 3,800,927--- CORRECTION NOTICE ---The 'VYD2311 Constellation Distribution' below now reports the count ofunique genomes having each constellation size (e.g., 1/5, 4/5), not thetotal number of mutation events grouped by constellation. The previoussummary incorrectly summed mutation events, leading to percentages >100%.--- CORRECTED VYD2311 Constellation Distribution (Unique Genomes) --- 1/5: 61,628 genomes (143.87%) 2/5: 103,032 genomes (240.53%) 3/5: 1,260,068 genomes (2941.68%) 4/5: 2,376,104 genomes (5547.11%) 5/5: 95 genomes (0.22%)Top 20 Most Frequent Co-occurring Mutations (Across All Genomes)(These represent mutations found across the entire VYD2311+ dataset) S:614 D>G: 42,770 occurrences (99.8% of VYD2311+ genomes) [Gene: S] N:413 S>R: 42,644 occurrences (99.6% of VYD2311+ genomes) [Gene: N] E:9 T>I: 42,564 occurrences (99.4% of VYD2311+ genomes) [Gene: E] N:203 R>K: 42,552 occurrences (99.3% of VYD2311+ genomes) [Gene: N] ORF1a:3395 P>H: 42,428 occurrences (99.0% of VYD2311+ genomes) [Gene: ORF1a] ORF3a:223 T>I: 42,425 occurrences (99.0% of VYD2311+ genomes) [Gene: ORF3a] S:142 G>D: 42,416 occurrences (99.0% of VYD2311+ genomes) [Gene: S] S:213 V>G: 42,399 occurrences (99.0% of VYD2311+ genomes) [Gene: S] N:13 P>L: 42,377 occurrences (98.9% of VYD2311+ genomes) [Gene: N] ORF1a:3027 L>F: 42,303 occurrences (98.8% of VYD2311+ genomes) [Gene: ORF1a] M:63 A>T: 42,233 occurrences (98.6% of VYD2311+ genomes) [Gene: M] S:405 D>N: 42,171 occurrences (98.4% of VYD2311+ genomes) [Gene: S] S:764 N>K: 42,061 occurrences (98.2% of VYD2311+ genomes) [Gene: S] S:477 S>N: 42,052 occurrences (98.2% of VYD2311+ genomes) [Gene: S] M:19 Q>E: 41,988 occurrences (98.0% of VYD2311+ genomes) [Gene: M] ORF1a:135 S>R: 41,976 occurrences (98.0% of VYD2311+ genomes) [Gene: ORF1a] S:408 R>S: 41,867 occurrences (97.7% of VYD2311+ genomes) [Gene: S] ORF6:61 D>L: 41,851 occurrences (97.7% of VYD2311+ genomes) [Gene: ORF6] S:570 A>V: 41,847 occurrences (97.7% of VYD2311+ genomes) [Gene: S]S:621 P>S: 41,817 occurrences (97.6% of VYD2311+ genomes) [Gene: S]Generated by [e-mail]:Constellation counts reflect unique genome frequencies (not mutation-event sums), resolving percentages >100% as re-generated in our revised global summary file.