Characterization of the Angiosarcoma Microenvironment

Angiosarcomas are ultra-rare, highly aggressive sarcomas with limited treatment options and dismal prognosis. In this project, we quantified immune cell infiltrates in the angiosarcoma tumor microenvironment. Unsupervised clustering was applied to reveal prognostically significant immune phenotypes. Proteomic profiling of 88 angiosarcoma samples (54 primary tissue, 17 local relapse tissue, and 17 metastatic tissue), 20 benign control tissues and 9 pooled groups was performed by LC–MS/MS to compare various AS subtypes, as well as up- and downregulated pathways between immune cell clusters.