Transcription profiling by array of human breast cancer cell lines BT20 and SKBR3 comparing mock clones to SFRP1 expressing clones to determine those molecules, genes and biochemical pathways modulated after forced SFRP1 re-expression

SFRP1 functions as an important inhibitor of the Wnt pathway and is a known tumor suppressor gene, which is epigenetically silenced in a variety of tumors. Nevertheless, too little is known about signaling pathways modulated by forced SFRP1 re-expression in dependency of the molecular breast cancer subtypes. In this study, we performed a systematic expression analysis of stably transfected human breast cancer cells to determine those molecules and biochemical pathways affected after forced SFRP1 re-expression.