IC50 values of four macitentan analogs and two bosentan analogs (tezosentan and clazosentan) obtained in calcium flux assays using transgenic cells expressing the indicated point-mutated ETA receptor variants.
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The right half of the table represents the loss in potency (fold IC50 shift) for each compound on each receptor variant compared to the wildtype receptor. IC50 values represent geometric means of n≥3 independent determinations.IC50 values of four macitentan analogs and two bosentan analogs (tezosentan and clazosentan) obtained in calcium flux assays using transgenic cells expressing the indicated point-mutated ETA receptor variants.
创建时间：
2015-12-02
