Development of a Nitrene-Type Rearrangement for the Commercial Route of the JAK1 Inhibitor Abrocitinib
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下载链接：
https://figshare.com/articles/dataset/Development_of_a_Nitrene-Type_Rearrangement_for_the_Commercial_Route_of_the_JAK1_Inhibitor_Abrocitinib/12977976
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资源简介：
The development of a commercial route
toward the JAK1 inhibitor
abrocitinib is described. The application of a late-stage Lossen rearrangement
provided the desired cis-diaminocyclobutane, which
was subsequently sulfonylated using a novel water-tolerable triazole
sulfonylating reagent to provide the active pharmaceutical ingredient.
创建时间：
2020-09-18
