首页/数据集/MLKL Activates cGAS-STING Pathway by Releasing Mitochondrial DNA Upon Necroptosis Induction. Ding et al

MLKL Activates cGAS-STING Pathway by Releasing Mitochondrial DNA Upon Necroptosis Induction. Ding et al

NIAID Data Ecosystem2026-05-02 收录

细胞程序性坏死机制

cGAS-STING信号通路

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These data were conected with "MLKL Activates cGAS-STING Pathway by Releasing Mitochondrial DNA Upon Necroptosis Induction" by Ding et al.

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创建时间：

2025-07-03

HIV-1免疫逃逸

cGAS-STING信号通路

The cyclic GMP-AMP synthase (cGAS) recognizes Y-form cDNA of HIV-1 and initiate the antiviral immune response through cGAS–STING–TBK1–IRF3–type I IFN (IFN-I) signaling cascade. HIV-1 uses several stra

NIAID Data Ecosystem50

ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage/cGAS-STING activation [B16 vivo]

肿瘤免疫治疗

cGAS-STING信号通路

Novel approaches are needed to boost the efficacy of immune checkpoint blockade (ICB) therapy. Ataxia Telangiectasia Mutated (ATM) protein plays a central role in sensing DNA double strand breaks an

NIAID Data Ecosystem30

IFNλ1 is a STING-dependent mediator of DNA damage and induces Immune activation in lung cancer. IFNλ1 is a STING-dependent mediator of DNA damage and induces Immune activation in lung cancer

肺癌免疫治疗

cGAS-STING信号通路

Introduction: The importance of the cGAS-STING pathway and type I interferon (IFN) in anti-tumor immunity has been widely studied. However, there is limited knowledge about the role of type III IFNs i

NIAID Data Ecosystem10

Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']

病毒蛋白结构

cGAS-STING信号通路

Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3'] Descriptor: 2',5'-GpAp, Protein B2 Authors: Eaglesham, J.B, Kranzusch, P.J. Deposit date: 2018-08-02 Release date: 2019-02-06 Last m

Protein Data Bank Japan2024-03-13 更新40

Gene expression in lung tissue, blood and spleen of mice with severe acute pancreatitis

胰腺炎分子机制

cGAS-STING信号通路

Severe acute pancreatitis (SAP) is a critical disease, often complicated with multiple organ dysfunction, which seriously endangeres the life safety of patients. Previous studies have shown that cGAS-

NIAID Data Ecosystem10

MLKL Activates cGAS-STING Pathway by Releasing Mitochondrial DNA Upon Necroptosis Induction. Ding et al

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