Identification of novel HSP90 / isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington s disease
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Identification of novel HSP90 / isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington s disease Descriptor: 8-(2-methylpropyl)-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-3,4-dihydroisoquinolin-1(2H)-one, Heat shock protein HSP 90-alpha Authors: Zuccola, H.J, Ernst, J.T. Deposit date: 2013-12-13 Release date: 2014-04-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Identification of Novel HSP90 alpha / beta Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington's Disease. J.Med.Chem., 57, 2014
本研究采用基于结构的药物设计策略发现新型HSP90亚型选择性抑制剂，并验证了其用于治疗亨廷顿病等中枢神经系统（Central Nervous System, CNS）疾病的潜在应用价值。
表征信息：8-(2-甲基丙基)-6-(3,6,6-三甲基-4-氧代-4,5,6,7-四氢-1H-吲哚-1-基)-3,4-二氢异喹啉-1(2H)-酮，热休克蛋白90α（Heat Shock Protein 90-alpha, HSP90α）
作者：Zuccola H.J.、Ernst J.T.
提交日期：2013年12月13日
发布日期：2014年4月9日
最后修改日期：2024年2月28日
实验方法：X射线衍射（分辨率1.96埃）
引用文献：Zuccola H.J., Ernst J.T. 基于结构药物设计发现新型HSP90α/β亚型选择性抑制剂并验证其治疗亨廷顿病等中枢神经系统疾病的潜在应用价值[J]. 药物化学杂志（Journal of Medicinal Chemistry, J.Med.Chem.）, 2014, 57.
创建时间：
2013-12-13
