Bacillus anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP120J

Bacillus anthracis Dihydrofolate Reductase bound to propargyl-linked TMP analog, UCP120J Descriptor: 6-ethyl-5-[3-(4-methoxybiphenyl-3-yl)prop-1-yn-1-yl]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Anderson, A.C, Beierlein, J.M. Deposit date: 2011-06-02 Release date: 2012-06-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-Activity Studies of Heterocyclic Propargyl-linked TMP Analogs Targeting Bacillus anthracis Dihydrofolate Reductase To be Published炭疽芽孢杆菌（Bacillus anthracis）二氢叶酸还原酶（Dihydrofolate Reductase）与炔丙基连接的甲氧苄啶（TMP）类似物UCP120J结合复合物 描述参数：6-乙基-5-[3-(4-甲氧基联苯-3-基)丙-1-炔-1-基]嘧啶-2,4-二胺、二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸（NADP） 作者：Anderson A.C.、Beierlein J.M. 入库日期：2011-06-02 发布日期：2012-06-13 最后修改日期：2023-09-13 实验方法：X射线衍射（分辨率1.9埃） 引用文献：《靶向炭疽芽孢杆菌二氢叶酸还原酶的杂环炔丙基连接甲氧苄啶类似物的构效关系研究》（待发表）