Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 17

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 17 Descriptor: (2R)-4-[2-(6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridin-1-yl)-2-oxoethyl]-2-methylpiperazin-1-ium, E3 ubiquitin-protein ligase XIAP, ZINC ION Authors: Chessari, G, Buck, I.M, Day, J.E.H, Day, P.J, Iqbal, A, Johnson, C.N, Lewis, E.J, Martins, V, Miller, D, Reader, M, Rees, D.C, Rich, S.J, Tamanini, E, Vitorino, M, Ward, G.A, Williams, P.A, Williams, G, Wilsher, N.E, Woolford, A.J.-A. Deposit date: 2015-06-24 Release date: 2015-08-12 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. J.Med.Chem., 58, 2015

靶向凋亡蛋白抑制剂的基于片段的药物发现（Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins）：化合物17 分子表征：(2R)-4-[2-(6-氯-2,3-二氢-1H-吡咯并[3,2-c]吡啶-1-基)-2-氧代乙基]-2-甲基哌嗪-1-鎓、E3泛素连接酶（E3 ubiquitin-protein ligase）XIAP、锌离子（zinc ion）
作者：Chessari, G、Buck, I.M、Day, J.E.H、Day, P.J、Iqbal, A、Johnson, C.N、Lewis, E.J、Martins, V、Miller, D、Reader, M、Rees, D.C、Rich, S.J、Tamanini, E、Vitorino, M、Ward, G.A、Williams, P.A、Williams, G、Wilsher, N.E、Woolford, A.J.-A.
提交日期：2015-06-24
发布日期：2015-08-12
最后修改日期：2024-05-08
实验方法：X射线衍射（X-ray diffraction，2.25 Å）
引用文献：靶向凋亡蛋白抑制剂的基于片段的药物发现：发现兼具cIAP1与XIAP双活性的非丙氨酸先导化合物系列。《J.Med.Chem.》，58卷，2015年