Appendix 4.3.4: PAML-BEB selected site analysis
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To validate our findings from aBSREL and MEME using a different method, we applied Phylogenetic Analysis by Maximum Likelihood (PAML) branch by site analysis to the luciferase sequences. We tested the alternative hypothesis, that there is a class of sites under selection (ω > 1) on the EAncLuc ancestral branch identified as under selection in the aBSREL analysis, against the null hypotheses, that all classes of sites on all branches are evolving either under constraint (ω
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2018-08-13
