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A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity

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Screen of an actinomycetes library yields antimalarial candidates that are non-toxic. A compound purified from an active extract, PDE-I2, potently inhibits P.falciparum proliferation. GraphPad Prism data are included, supporting figures 4-6, S1,2,4,5, and Table S1
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2021-10-18
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