A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity

Screen of an actinomycetes library yields antimalarial candidates that are non-toxic. A compound purified from an active extract, PDE-I2, potently inhibits P.falciparum proliferation. GraphPad Prism data are included, supporting figures 4-6, S1,2,4,5, and Table S1对放线菌文库进行筛选，获得了无毒的抗疟候选化合物。从活性提取物中纯化得到的化合物PDE-I2，可强效抑制恶性疟原虫（Plasmodium falciparum）的增殖。本数据集包含GraphPad Prism分析所得数据，用于支撑图4至6、补充图S1、S2、S4、S5及补充表S1。