Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington’s disease

This is a longitudinal project using diffusion MRI (DTI and FBA) across different ages in the zQ175DN HET mouse model of Huntington's disease and age-matched wildtype littermates. Additionally, ex vivo Luxol Fast Blue (LFB) staining on brain tissue and blood plasma Neurofilament Light (NfL) chain protein quantification was performed. This data set has been used in the following publication: "Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington’s disease" by Vidas-Guscic et al. (2024).本研究为一项纵向研究，针对亨廷顿舞蹈病的zQ175DN杂合小鼠模型与年龄匹配的野生型同窝仔鼠，在不同年龄段采用弥散磁共振成像（diffusion MRI）技术，包含弥散张量成像（Diffusion Tensor Imaging, DTI）与纤维束分析（Fiber Bundle Analysis, FBA）两种技术路径。此外，本研究还完成了脑组织离体卢卡斯坚牢蓝（Luxol Fast Blue, LFB）染色，以及血浆神经丝轻链（Neurofilament Light, NfL）蛋白的定量检测。该数据集已被用于以下学术出版物：Vidas-Guscic等人2024年发表的《弥散磁共振成像揭示亨廷顿舞蹈病zQ175DN小鼠模型中纤维完整性的进行性改变》。