Characterization of AR interactome in prostate cancer cells after MC3324 treatment

NIAID Data Ecosystem2026-03-14 收录

前列腺癌药物机制

AR相互作用组分析

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https://www.omicsdi.org/dataset/pride/PXD029249 数据链接链接失效反馈

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We here investigated the alterations in the androgen receptor (AR) itneractome after treatment with the dual-KDM inhibitor MC3324.

创建时间：

2022-10-13

miRNA array analysis following gefinitib/luteolin administration to PC-3 cells

前列腺癌药物机制

miRNA表达分析

To determine if any altered miRNA expression is actually involved in the growth inhibition and/or cell death induction by luteolin and/or gefitinib, we performed miR-array analysis using RNA from PC-3

NIAID Data Ecosystem70

"Drug-seq": An Approach to Identify the Genomic Targets of Chemicals Identified by Functional Phenotypic Screens [Drug-seq]. Homo sapiens

药物基因组靶点识别

前列腺癌药物机制

Here we report an approach that has permitted us to uncover the sites and mechanisms of action of a drug, referred to as SD70, initially identified by phenotypic screening for inhibitors of ligand and

NIAID Data Ecosystem40

Small molecule-induced bioenergetic reprogramming directs prostate cancer inhibition via UPR signaling. Homo sapiens

前列腺癌药物机制

小分子诱导凋亡

We previously identified SMIP004 (N-(4-butyl-2-methyl-phenyl) acetamide), as a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells. SMIP004 decreased the levels of positive

NIAID Data Ecosystem20

Effect of AZD1208 on gene expression in recurrent resistant Myc-CaP tumors grown in castrated mice.

前列腺癌药物机制

基因表达谱分析

AZD1208 is a novel PIM kinase inhibitor that we have shown inhibits tumorigenesis in tissue recombination models, Myc-CaP allograft models, and human prostate cancer xenografts. We sought to determine

NIAID Data Ecosystem40

The HDAC Inhibitor LBH589 Induces ERK-Dependent Prometaphase Arrest in Prostate Cancer via HDAC6 Inactivation and Down-Regulation

前列腺癌药物机制

HDAC6信号通路

Histone deacetylase inhibitors (HDACIs) have potent anti-cancer activity in a variety of cancer models. Understanding the molecular mechanisms involved in the therapeutic responsiveness of HDACI is ne

NIAID Data Ecosystem40

Characterization of AR interactome in prostate cancer cells after MC3324 treatment

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