TBEVHostDB

TBEVHostDB — a catalog of human genes that are probably involved in response to TBEV infection. It was created based on manual review and curation of scientific publications. If the publication described a non-human mammalian gene/protein, the homologous human gene was found and included into the catalog. At present a catalog contains 140 human genes. Genes are classified into functional categories (datasets) according to five types of evidence: (1) genes encoding proteins that had direct physical interactions with TBE viral particle, TBEV proteins or RNA.; (2) genes encoding mRNAs (or proteins) that were up- or down-regulated in response to TBEV infection ; (3) allelic variants in these genes are associated with susceptibility or resistance to TBEV infection; (4) these proteins were required for inhibitory effect of other proteins against TBEV or attenuated its antiviral activity; (5) knockout of these genes in mice increased mortality rates or affected the other clinical manifestations of the disease.TBEVHostDB — 一款收录可能参与蜱传脑炎病毒（Tick-borne encephalitis virus, TBEV）感染应答过程的人类基因目录。该目录基于对科学文献的人工审阅与整理构建而成。若文献中描述的为非人类哺乳动物的基因/蛋白质，则会检索到其对应的同源人类基因并纳入该目录。目前该目录共收录140个人类基因。研究人员依据五类证据将这些基因划分为不同功能类别（数据集）：(1) 所编码蛋白质可与TBE病毒颗粒、TBEV蛋白或RNA发生直接物理相互作用的基因；(2) 所编码的mRNA（或蛋白质）在TBEV感染后呈现表达上调或下调的基因；(3) 该类基因的等位变异与TBEV感染的易感性或抗性相关的基因；(4) 这些蛋白质是其他蛋白质发挥抗TBEV抑制效应所必需的，或可减弱其抗病毒活性的基因；(5) 在小鼠体内敲除该类基因会提升小鼠死亡率，或影响该疾病的其他临床表现的基因。

搜集汇总

背景与挑战

背景概述

TBEVHostDB是一个基于科学文献手动整理的人类基因目录，收录了140个可能与TBEV感染反应相关的基因。这些基因根据五种证据类型进行分类，包括与TBEV的直接物理相互作用、表达调控、遗传变异关联、抗病毒活性影响以及小鼠基因敲除实验的临床效应。