Respiration status of complex I, II+III, and IV of the ETC was evaluated in fresh left ventricular tissue as described in the Materials and Methods. According to oxygen flux measures (pmol/mg/substrat

NIAID Data Ecosystem70

Diuretic Activity Report of JT09 in Sprague-Dawley Rats: Study Report Data

利尿活性评价

临床前药理学

This data set contains information regarding a diuretic activity study performed using a novel, peptide-derived, peripherally-restricted, kappa opioid agonist. The data outlines clinical chemistry and

Figshare2022-02-02 更新50

Characterization of the molecular mechanisms underlying sunitinib-induced cardiotoxicity via autophagy manipulated MYLK3 degradation

药物心脏毒性

酪氨酸激酶抑制剂副作用

Sunitinib, which is a kind of tyrosine kinases that can selectively target multiple receptors, exhibits antiangiogenic and antitumor activity, and extends survival of patients with metastatic renal-ce

NIAID Data Ecosystem10

Inhibition of PRKAA/AMPK (Ser485/491) phosphorylation by crizotinib induces cardiotoxicity via perturbing autophagosome-lysosome fusion

药物心脏毒性

自噬机制

Crizotinib, a small-molecule tyrosine kinase inhibitor targeting ALK, MET and ROS1, is the first-line drug for ALK-positive metastatic non-small cell lung cancer and is associated with severe, sometim

DataCite Commons2024-02-07 更新60

Effect of high-dose epinephrine on myocardial gene set expression

药物心脏毒性

心肌基因表达

Effect of high-dose epinephrine on myocardial gene set expression

ChEBI2023-05-31 更新40