HIPC-II Immune Signatures Data Resource

This file is a snapshot of all data included in the Immune Signatures Data Resource, which can be browsed in greater detail on ImmuneSpace at www.immunespace.org/is2.url. <br><br>Vaccines are among the most cost-effective public health interventions for preventing infection-induced morbidity and mortality, yet much remains to be learned regarding mechanisms. The NIH/NIAID Human Immunology Project Consortium(HIPC) has leveraged systems immunology approaches to identify molecular signatures of immunogenicity in many vaccines. These data are available to the scientific community through the ImmuneSpace data portal and analysis engine leveraging the NIH/NIAID ImmPort repository. However, a barrier to progress in this area is that comparative vaccine analyses have been limited by the distributed nature of some data, potential confounders, and the absence of relevant studies in ImmPort. To support comparative analysis, we have created the Immune Signatures Data Resource, a compendium of standardized systems vaccinology datasets available through ImmuneSpace, along with code to reproduce the standardization pipeline. The current release comprises 1405 participants from 53 cohorts profiling the response to 24 vaccines and includes transcriptional profiles and antibody response measurements. This novel compendium represents a valuable resource for comparative analyses that will accelerate our understanding of mechanisms underlying vaccine responses.