Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3OG

Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3OG Descriptor: 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 Authors: Neuberger, A, Nadezhdin, K.D, Singh, A.K, Sobolevsky, A.I. Deposit date: 2020-09-15 Release date: 2020-12-09 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.66 Å) Cite: Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020

人类TRPV6与(4-苯基环己基)哌嗪类抑制剂3OG结合的冷冻电镜（Cryo-EM）结构。结构描述符：5-[(4-{反式-4-羟基-4-[3-(三氟甲基)苯基]环己基}哌嗪-1-基)甲基]吡啶-2(1H)-酮、钙离子、瞬时受体电位阳离子通道亚家族V成员6（Transient receptor potential cation channel subfamily V member 6）。作者：Neuberger, A、Nadezhdin, K.D、Singh, A.K、Sobolevsky, A.I。存档日期：2020-09-15；发布日期：2020-12-09；最后修改日期：2025-05-21。实验方法：电子显微镜（分辨率3.66 Å）。引用文献：《上皮钙通道TRPV6的失活模拟阻断》，《科学进展》，2020年，第6卷。