Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
收藏Protein Data Bank Japan2024-02-28 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/3vbq
下载链接
链接失效反馈官方服务：
资源简介：
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design Descriptor: (5~{Z})-5-[[3-[6-[(4-azanylcyclohexyl)amino]pyrazin-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione, Serine/threonine-protein kinase pim-1 Authors: Liu, J. Deposit date: 2012-01-02 Release date: 2012-03-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
Pim-1激酶（Pim-1 kinase）针式筛选与抑制剂设计中氢键约束与平坦疏水能量景观的利用
描述符：(Z)-5-[[3-[6-[(4-氨基环己基)氨基]吡嗪-2-基]苯基]亚甲基]-1,3-噻唑烷-2,4-二酮、丝氨酸/苏氨酸蛋白激酶Pim-1（Serine/threonine-protein kinase pim-1）
作者：Liu, J.
存入日期：2012-01-02
发布日期：2012-03-21
最后修改日期：2024-02-28
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.85埃（1.85 Å）
引用文献：混杂型Pim-1激酶片段抑制剂疏水相互作用对基于片段的药物设计的启示。J.Med.Chem., 55, 2012
创建时间：
2012-01-02
