Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 1)

Crystal structure of a Fc fragment LALA mutant (L234A, L235A) of human IgG1 (crystal form 1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Uncharacterized protein DKFZp686C11235 Authors: Gohain, N, Tolbert, W.D, Pazgier, M. Deposit date: 2018-02-22 Release date: 2019-02-27 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fc gamma Receptor Binding. Structure, 2020

人源IgG1的Fc片段LALA突变体（L234A、L235A）晶体结构（晶型1）
描述物：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→3)-[2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→2)-α-D-吡喃甘露糖-(1→6)]β-D-吡喃甘露糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖，未表征蛋白DKFZp686C11235
作者：Gohain N、Tolbert W.D、Pazgier M
沉积日期：2018-02-22
发布日期：2019-02-27
最后修改日期：2024-11-20
实验方法：X射线衍射（分辨率2.4 Å）
引用文献：《人源IgG1 Fc段的抗原诱导变构变化可增强低亲和力Fcγ受体结合能力》，《Structure》，2020年