Intersection between PAM and the Exclusive Recognition analysis.

The table lists peptides that were commonly defined by PAM (peptides with significant differences in the intensity of the response vs. the reference group D−R−) and as well in the ‘exclusive recognition analysis’ (never above a threshold for detection in the D−R− group). Peptides marked with a star (*) were above this threshold in all patients in the respective group but never in serum from D−R− patients. The average Q-value is the absolute difference between PAM Q-score for D−R− and the Q-score for each respective group. Higher average Q-value indicates the probability that the peptide is differently recognized between the respective group and the D−R− (reference) group.At 6 months, possible cross-reactivity to serum IgG for the epitope QPGENEVRPHAGVID (HCMV UL102) and the aminoacid sequence from a DNA packaging tegument protein UL17 from Herpes Simplex virus-1, which shows a matching alignment of 5 amino acids without any mismatch. Note at 12 months, a possible cross-reactivity of serum IgG for the epitope AQLDLEADPTAREGE (HCMV UL35) and the aminoacid sequence from a protein from Epstein-Barr virus, RNGATFSKGDIEGNF (HCMV US30), the Human herpesvirus-6A protein, the epitope YPAVTTVYPPSSTAK and YDDESWRPLSTVDDH directed against proteins from Human herpesvirus 8, could be found. At 24 months, no matches (using the criteria outlined in materials and methods) between serum CMV epitope recognition and proteomes of other human herpesviruses were found.