Protein Kinase B/Akt phosphorylates BRF1

BRF1 is phosphorylated at Serine92 and Serine203 by Protein kinase B/AKT. Protein kinase B is activated by phosphatidylinositol 3-kinase. Phosphorylation of BRF1 does not interfere with the ability of BRF1 to bind RNA or interact with enzymes that catalyze RNA degradation therefore larger complexes may contain phosphorylated BRF1.

BRF1蛋白在丝氨酸92和丝氨酸203位点上被蛋白激酶B/AKT磷酸化。蛋白激酶B的激活依赖于磷脂酰肌醇3激酶。BRF1的磷酸化不影响其与RNA的结合能力或与催化RNA降解的酶的相互作用，因此较大的复合物中可能包含磷酸化的BRF1。