Structure of human Bcl-2 in complex with ABT-263

Structure of human Bcl-2 in complex with ABT-263 Descriptor: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1 Authors: Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. Deposit date: 2019-01-11 Release date: 2019-06-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1. Acs Omega, 4, 2019

人Bcl-2与ABT-263复合物的结构
描述：4-(4-{[2-(4-氯苯基)-5,5-二甲基环己-1-烯-1-基]甲基}哌嗪-1-基)-N-[(4-{[(2R)-4-(吗啉-4-基)-1-(苯硫基)丁-2-基]氨基}-3-[(三氟甲基)磺酰基]苯基)磺酰基]苯甲酰胺，凋亡调节蛋白Bcl-2（Apoptosis regulator Bcl-2）、Bcl-2样蛋白1（Bcl-2-like protein 1），凋亡调节蛋白Bcl-2（Apoptosis regulator Bcl-2）、Bcl-2样蛋白1（Bcl-2-like protein 1）
作者：Dokurno, P.、Murray, J.、Davidson, J.、Chen, I.、Davis, B.、Graham, C.J.、Harris, R.、Jordan, A.M.、Matassova, N.、Pedder, C.、Ray, S.、Roughley, S.、Smith, J.、Walmsley, C.、Wang, Y.、Whitehead, N.、Williamson, D.S.、Casara, P.、Le Diguarher, T.、Hickman, J.、Stark, J.、Kotschy, A.、Geneste, O.、Hubbard, R.E.
入库日期：2019-01-11
发布日期：2019-06-12
最后修改日期：2024-01-24
实验方法：X射线衍射（分辨率2 Å）
引用文献：《靶向抗凋亡蛋白Bcl-2与Mcl-1的药物发现及命中系列鉴定》，ACS Omega，4卷，2019年