HLA Association with ALL

This retrospective case–control study analyzed 137 ALL patients and 350 ethnically-matched controls using six‑digit NGS typing of HLA‑A, ‑B, ‑C, ‑DRB1, ‑DQA1, ‑DQB1, and ‑DPB1 loci. NGS-based high-resolution typing identified novel, population-specific HLA associations with ALL in ethnic Kazakhs, with class II effects predominating and additional class I signals at HLA-B and HLA-C.